| Awards |
| 2001 MBC Drama Awards |
|
|
| Best New Actor |
Her House |
Won |
| 2003 MBC Drama Awards |
|
|
| Excellence Award, Actor |
Damo |
Won |
| Popularity Award, Actor |
Damo |
Nominated |
| Best Couple Award |
Lee Seo-jin with Ha Ji-won in Damo |
Won |
| 2004 MBC Drama Awards |
|
|
| Top Excellence Award, Actor |
Phoenix |
Won |
| Popularity Award, Actor |
Phoenix |
Nominated |
| Best Couple Award |
Lee Seo-jin with Lee Eun-ju in Phoenix |
Won |
| 2006 SBS Drama Awards |
|
|
| Netizen Popularity Award, Actor |
Lovers |
Won |
| Top 10 Stars |
Lovers |
Won |
| 2007 MBC Drama Awards |
|
|
| Top Excellence Award, Actor |
Yi San |
Won |
| Popularity Award, Actor |
Yi San |
Nominated |
| Best Couple Award |
Lee Seo-jin with Han Ji-min in Yi San |
Nominated |
| 2008 44th Baeksang Arts Awards |
|
|
| Best Actor - Television |
Yi San |
Nominated |
| 2013 Style Icon Awards |
|
|
| Style Icon |
Lee Seo-jin |
Won |
| 2014 3rd APAN Star Awards |
|
|
| Top Excellence Award, Actor in a Serial Drama |
Wonderful Days |
Nominated |
| 2014 KBS Drama Awards |
|
|
| Excellence Award, Actor in a Serial Drama |
Wonderful Days |
Nominated |
| Netizen Award, Actor |
Wonderful Days |
Nominated |
| Best Couple Award |
Lee Seo-jin with Kim Hee-sun in Wonderful Days |
Nominated |
| 2016 MBC Drama Awards |
|
|
| Grand Prize (Daesang) |
Marriage Contract |
Nominated |
| Top Excellence Award, Actor in a Special Project Drama |
Marriage Contract |
Won |
| Best Couple Awardc |
Lee Seo-jin with Uee in Marriage Contract |
Nominated |
| 2016 tvN10 Awards |
|
|
| Grand Prize (Daesang), Variety Performer |
Three Meals a Day: Jeongseon Village, Grandpas Over Flowers |
Won |
| Variety Icon |
Three Meals a Day: Jeongseon Village |
Nominated |